Hello.
The ads are pretty intrusive in my opinion, you may wish to push them to the two sides.
Also, it may be just me, but I don't really think the images on your homepage are especially funny. Maybe you should list all the funniest images on your homepage? This will allow visitors to be attracted to your site on the first go.
Also, since your site deals with best funny images, maybe you can even design a logo that is hilarious. This will fit the theme of your site, and help build up your branding as well.
Just a few suggestions, employ them as you see fit.
